CDP-choline is composed primarily of choline and uridine, two molecules which are important to our cognitive faculties and overall well-being. It can help boost your mental acuity, as studies suggest this increase is linked to improved circulation and oxygen absorption as a result of CDP-choline supplementation.^[1] In one study, women ranging in age from 40 to 60 showed a significant improvement in their attention span and ability to focus on a given test.^[2]

Part of the effectiveness of CDP-choline is related to its ability to boost acetylcholine levels in the brain. Acetylcholine is a neurotransmitter that is involved in memory and cognitive function; low acetylcholine levels have been linked to memory loss and cognitive decline. CDP-choline has been shown to increase acetylcholine levels following a stroke or traumatic brain injury.^[3]

It is also involved in your body’s ability to signal and transport dopamine; while CDP-choline doesn’t necessary help your body synthesis or create more dopamine, it does help your dopamine receptors and transporters, meaning that your dopamine is more readily available.^[4] It has been suggested as a possible treatment option for Parkinson’s disease,^[5] which is the most well-known condition produced by low dopamine levels.

CDP-choline has what are known as neuroprotection capabilities, meaning that it can protect your brain cells from toxicity and damage. Rats who took CDP-choline at the beginning of a forced stroke showed significantly less damage than rats who were not given the supplement.^[6] A similar study which focused on brain damage rather than stroke showed rats who were given CDP-choline retained significant portions of their memory.^[7] Human subjects who were given CDP-choline after a traumatic brain injury, coma, and concussion, were associated with a faster recovery time in terms of memory and cognition.^[8]

CDP-choline has been shown to have its greatest memory-boosting effects on aged rats who are already suffering some form of memory loss or cognitive impairment. Rats who were given the supplement for 8 weeks showed a reversal of the spatial memory loss that is common with aging.^[9] It has also been shown to improve results on active avoidance tests in both young and elderly rats. Active avoidance tests use fear or pain as a consequence of pushing the wrong button or performing some other task, and are used to judge learning and memory. Rats given CDP-choline were able to learn what to avoid much quicker than rats who were not given the supplement.^[10] Studies performed on humans have had similarly positive effects – in healthy, aged human subjects, CDP-choline supplementation resulted in significant increase in memory formation and recall.^[11]

CDP-choline also supports cell health and communication throughout your entire brain and body, as it elements known as phospholipids, which are crucial ingredients in neuronal cell membranes.

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References
1. http://nootriment.com/cdp-choline/
2. http://www.scirp.org/journal/PaperInformation.aspx?paperID=19921
3. http://www.ncbi.nlm.nih.gov/pubmed/9104933
4. http://www.ncbi.nlm.nih.gov/pubmed/1839138
5. Eberhardt R, Birbamer G, Gerstenbrand F, et al. Citicoline in the treatment of Parkinson's disease. Clin Ther. 1990;12:489-495.
6. http://www.ncbi.nlm.nih.gov/pubmed/10390324
7. http://www.ncbi.nlm.nih.gov/pubmed/9104933
8. http://www.ncbi.nlm.nih.gov/pubmed/8709678
9. http://www.ncbi.nlm.nih.gov/pubmed/12787861
10. http://www.ncbi.nlm.nih.gov/pubmed/1494300
11. http://www.ncbi.nlm.nih.gov/pubmed/9203170