Unlike other antioxidants, which work only in water or fatty tissues, Alpha Lipoic Acid’s broader spectrum of antioxidant action results from its ability to function in both water and fat.^[1,2] By comparison, vitamin E works only in fat and vitamin C works only in water. In addition, Alpha Lipoic Acid may be able to do the work of other antioxidants when the body is deficient in them.^[3,4] 

Because it plays a part in cellular energy production, some nutritionally oriented physicians recommend Alpha Lipoic Acid for the treatment of chronic fatigue syndrome.^[5] While evidence of its effectiveness for this condition is anecdotal, Alpha Lipoic Acid is a broad-spectrum antioxidant and immune system booster. This means it may be able to play a valuable role in increasing energy and maintaining overall health in chronic fatigue syndrome sufferers. 

Several papers found R-(+)-Lipoic Acid and Acetyl-L-Carnitine reversed age-related markers in old rats to youthful levels.^[6-12] 

R-(+)-Lipoic Acid may function in vivo like a B-vitamin, and at higher doses like plant-derived nutrients, such as resveratrol, which induce phase II detoxification enzymes.^[13,14] This stress response indirectly improves the antioxidant capacity of the cell.^[15] 

The antioxidant effects of Alpha Lipoic Acid were demonstrated when it was found to prevent the symptoms of vitamin C and vitamin E deficiency.^[16] 

All Weyland Brain Nutrition products are manufactured in the USA at an FDA inspected cGMP and 3rd party rated facility. We guarantee your satisfaction or we will refund 100% of your purchase, including shipping costs for up to one bottle of each Weyland Brain Nutrition product per customer.

References
1. ISuzuki YJ, Tsuchiya M, Packer L. Lipoate prevents glucose-induced protein modifications. Free Radic Res Commun. 1992;17:211-217.
2. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in 
    patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med. 1999;27:309-314. 
3. Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med. 
    1995;19:227-250. 
4. Podda M, Tritschler HJ, Ulrich H, et al. Alpha-lipoic acid supplementation prevents symptoms of vitamin E 
    deficiency. Biochem Biophys Res Commun. 1994;204:98-104. 
5. Logan AC, Wong C. Chronic fatigue syndrome: Oxidative stress and dietary modifications. Altern Med Rev. 
    2001 Oct;6(5):450-9. 
6. Lecoq R, Chauchard P, Mazoue H (October 1958). "Comparative chronaxymetric research on the effects of 
    several vitaminic substances (stigmasterol, carnitine, thioctic acid)". Comptes rendus hebdomadaires des 
    seances de l'Academie des sciences 247 (17): 1411–3. PMID 13609011 
7. McCarty MF (April 1981). "Toward a "bio-energy supplement" -- a prototype for functional orthomolecular 
    supplementation". Medical hypotheses 7 (4): 515–38. doi:10.1016/0306-9877(81)90038-4. PMID 6793816 
8. Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN (Sep 1998). "Age-associated decline in ascorbic acid 
    concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid 
    supplementation". FASEB J. 12 (12): 1183–9. PMID 9737721 
9. Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames AB (February 
    1999). "(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative 
    damage, and increased metabolic rate". The FASEB journal : official publication of the Federation of American 
    Societies for Experimental Biology 13 (2): 411–8. PMID 9973329 
10. Hagen TM, Vinarsky V, Wehr CM, Ames BN (2000). "(R)-alpha-lipoic acid reverses the age-associated 
    increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo". Antioxidants & 
    redox signaling 2 (3): 473–83. doi:10.1089/15230860050192251. PMID 11229361 
11. Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN (February 
    2002). "Feeding acetyl-l-carnitine and lipoic acid to old rats significantly improves metabolic function while 
    decreasing oxidative stress". Proceedings of the National Academy of Sciences of the United States of 
    America 99 (4): 1870–5. doi:10.1073/pnas.261708898. PMC 122286. PMID 11854487 
12. Liu, J; Head, E; Gharib, AM; Yuan, W; Ingersoll, RT; Hagen, TM; Cotman, CW; Ames, BN (2002). "Memory 
    loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding 
    acetyl-l-carnitine and/or R-α-lipoic acid". Proceedings of the National Academy of Sciences of the United States 
    of America 99 (4): 2356–61. doi:10.1073/pnas.261709299. PMC 122369. PMID 11854529. Erratum in: Proc Natl 
    Acad Sci U S A 2002 May 14;99(10):7184-5 
13. Petersen-Shay K, Shenvi S, Hagen TM. Lipoic acid as an inducer of phase II detoxification enzymes through 
    activation of Nr-f2 dependent gene expression. Chapter 14 in Alpha Lipoic Acid: Energy Production, Antioxidant 
    Activity and Health Effects. Packer L, Patel M, eds. Boca Raton, New York, London: Taylor & Francis 
    Publishers (2008) 349-371; ISBN 978-1420045376 
14. Chong-Kuei Lii, Kai-Li Liu, Yi-Ping Cheng, Ai-Hsuan Lin, Haw-Wen Chen,Chia-Wen Tsai. Sulforaphane and 
    -Lipoic Acid Upregulate the Expression of the Class of Glutathione S-Transferase through c-Jun and Nrf2 
    Activation 1,2. J. Nutr (March 17, 2010) doi:10.3945/jn.110.121418 
15. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM (June 2008). "Is alpha-lipoic acid a scavenger of reactive 
    oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous 
    antioxidant capacity". IUBMB life 60 (6): 362–7. doi:10.1002/iub.40. PMID 18409172\ 
16. Murphy GE, Jensen GJ. (2005). "Electron cryotomography of the E. coli pyruvate and 2-oxoglutarate 
    dehydrogenase complexes". Structure 13 (12): 1765–1773. doi:10.1016/j.str.2005.08.016. PMID 16338405. [2] - See more at: http://www.myelebra.com/Alpha-Lipoic-Acid.html#sthash.XjTpoS3T.dpuf